Clarigenic Tri-Clear amber bottle on travertine stone beside a linen cloth and loose capsules

The Tri-Pathway system for clearer-looking skin.

Research-backed nutrients that help balance oil, defend against oxidative stress, and support calmer, clearer-looking skin from within.*

You’re on the pre-order list.Thank you. No payment has been taken. We’ll email you when ordering opens, with pricing and ship date.

Backed by research

Every ingredient is backed by published research, cited study by study.

See the science

Clean & non-toxic

Disclosed doses, no artificial colors, no proprietary blends.

Clean ingredients

Guaranteed

Try it for 90 days. If you don’t love your results, we’ll refund your first order.

The guarantee

The Tri-Pathway system

One system. Three pathways. Working together.

How clear skin looks comes down to more than one thing. Instead of a single hero ingredient, Tri-Clear is built as a system that supports three of skin’s own pathways at the same time, with every dose on the label.*

01 · PATHWAY

Oil balance

Helps keep skin’s oil production in balance, so skin looks less shiny and pores look clearer.*

02 · PATHWAY

Antioxidant defense

Supports skin’s own antioxidant defenses against everyday oxidative stress, for a fresher, healthier-looking complexion.*

03 · PATHWAY

Calm & repair

Supports a calmer-looking complexion and skin’s natural renewal, day after day.*

The science

The science of clearer-looking skin.

Research has looked at how specific nutrients support oil balance, antioxidant defense and a calmer-looking complexion. Tri-Clear is built on that research. Here’s what it found, in plain English, with a link to every paper.

01 · Oil balance

Over 12 weeks, people taking the supplement saw a greater drop in blemishes than those on placebo.*

In a small randomized, double-blind study (41 people evaluated), adults with blemish-prone skin took a vitamin B5-based supplement or a placebo. The supplement group saw a significantly greater reduction in total blemish count, and it was well tolerated.

Yang M, Moclair B, Hatcher V, et al. A randomized, double-blind, placebo-controlled study of a novel pantothenic acid-based dietary supplement in subjects with mild to moderate facial acne. Dermatology and Therapy. 2014;4(1):93–101. PubMed 24831048 · doi:10.1007/s13555-014-0052-3

02 · Antioxidant defense

Research links cystine, the paired form of cysteine, to smoother texture, less redness and a more even-looking tone.*

In a 12-week placebo-controlled study of young women with skin imperfections, a cystine-and-collagen supplement improved skin texture and reduced redness. In another, L-cystine with glutathione led to a more even-looking tone and smaller-looking dark spots than placebo. Cysteine is also what the body uses to make glutathione, its own key antioxidant.

Perin F, Bruno-Bonnet C, Soulard J-P, et al. Effects of oral fish collagen and l-cystine on skin ageing in mature women and skin imperfections in young women: findings from two randomised, three-arm, double-blind, placebo-controlled studies. Cosmetics. 2025;12(5):188. doi:10.3390/cosmetics12050188

Duperray J, Sergheraert R, Chalothorn K, et al. The effects of the oral supplementation of L-Cystine associated with reduced L-Glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial. Journal of Cosmetic Dermatology. 2022;21(2):802–813. PubMed 33834608 · doi:10.1111/jocd.14137

Lu SC. Glutathione synthesis. Biochimica et Biophysica Acta. 2013;1830(5):3143–3153. PubMed 22995213 · doi:10.1016/j.bbagen.2012.09.008

03 · Calm & repair

Blemish-prone skin has been linked to lower zinc levels, and zinc to fewer inflamed blemishes.*

A 2020 review and meta-analysis found lower average blood zinc in people with acne, and fewer inflamed blemishes with zinc.

Yee BE, Richards P, Sui JY, Marsch AF. Serum zinc levels and efficacy of zinc treatment in acne vulgaris: a systematic review and meta-analysis. Dermatologic Therapy. 2020;33(6):e14252. PubMed 32860489 · doi:10.1111/dth.14252

These studies looked at individual ingredients, often in different forms or amounts, not at Tri-Clear itself.

Clean ingredients

Clean, non-toxic, and readable.

Natural nutrients designed to put your skin back in balance.

No proprietary blends. Every ingredient and every dose is on the label.
No artificial colors or dyes, and no titanium dioxide.
No artificial flavors or sweeteners. It’s a capsule, not a candy.
Plant-based capsule shell, with only the minimal fillers needed to make the capsule.
Third-party tested: every batch is lab-tested for identity, potency, heavy metals and microbes before it ships.

Our guarantee

Try it for 90 days. If you don’t love your results, we’ll refund your first order.^†

Skin takes time, so we give it time. Try it for 90 days from the day your first bottle arrives. If you don’t love your results, we’ll refund your first order.

FAQ

Good questions.

Something else on your mind? Write to us at hello@clarigenicskin.com.

When can I order?

Join the pre-order list and we’ll email you when ordering opens, with pricing and the ship date.

Do I pay anything now?

No. Joining the pre-order list is free and takes no payment. When ordering opens, we’ll email you the price and ship date, and you can decide then.

What is the Tri-Pathway system?

It’s the idea behind Tri-Clear: instead of a single ingredient, 3 capsules a day support three of skin’s own pathways together. Those are oil balance (vitamin B5), antioxidant defense (L-cysteine), and calm & repair (zinc, balanced with copper).*

What’s in Tri-Clear?

Per serving of 3 capsules: pantothenic acid (vitamin B5) 1,000 mg, L-cysteine 500 mg, zinc 25 mg and copper 2 mg. Other ingredients: capsule shell; full list on the label. 90 capsules, a 30-day supply.

How do I take it?

Three capsules, once a day, with food. Taking it with a meal is easier on the stomach, especially with zinc.

How long until I notice a difference?

Everyone’s skin is different, and skin renews itself gradually over several weeks. We suggest consistent daily use, which is why our guarantee gives you a full 90 days.

Can I take it with my other supplements?

Check your other products for zinc and copper so your total stays within daily upper limits (40 mg of zinc and 10 mg of copper for adults). If you’re pregnant, nursing, taking medication (zinc can interact with some antibiotics), or have a medical condition, ask your healthcare provider first.

How does the 90-day guarantee work?

Try it for 90 days from the day your first bottle arrives. If you don’t love your results, we’ll refund your first order. One refund per customer; full terms at checkout. To request a refund, email hello@clarigenicskin.com.

The pre-order list

Clearer-looking skin, from within.

We’ll email you when ordering opens, with pricing and the ship date, plus a short note on the science behind each pathway. Free to join, no payment now.